KMID : 0545120220320080955
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Journal of Microbiology and Biotechnology 2022 Volume.32 No. 8 p.955 ~ p.959
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Emerging Japanese Encephalitis Virus Genotype V in Republic of Korea
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Lee Ah-Ra
Song Jae-Min Seo Sang-Uk
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Abstract
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Japanese encephalitis (JE) is a vaccine-preventable mosquito-borne disease caused by infection with the Japanese encephalitis virus (JEV). JEV has five genotypes, including genotype V (GV), which is considered ancestral to the other genotypes. The first GV strain, GV Muar, was isolated from a Malayan patient in 1952 and GV did not reappear for 57 years until GV XZ0934 was isolated from a mosquito sample in China. Since 2010, 21 GV strains have been identified in Republic of Korea (ROK). Both GV Muar and GV XZ0934 are more pathogenic than other GI/GIII strains and are serologically distinct. However, because the ROK¡¯s GV strains have not been experimentally tested, their characteristics are not known. Characterization of the ROK¡¯s isolates is needed to enable development of effective GV strain-based vaccines to protect against GV infections.
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KEYWORD
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